Academic interests
Mental disorders. Transmission of psychological traits across generations. Genetically informative designs.
Courses taught
PSY9140 – Introduction to structural equation modelling
Publications
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Slapø, Nora Berz; Jørgensen, Kjetil Nordbø; Elvsåshagen, Torbjørn; Nerland, Stener; Roelfs, Daniel & Valstad, Mathias
[Show all 18 contributors for this article]
(2023).
Relationship between function and structure in the visual cortex in healthy individuals and in patients with severe mental disorders.
Psychiatry Research : Neuroimaging.
ISSN 0925-4927.
332.
doi:
10.1016/j.pscychresns.2023.111633.
Full text in Research Archive
Show summary
Patients with schizophrenia spectrum disorders (SCZspect) and bipolar disorders (BD) show impaired function in the primary visual cortex (V1), indicated by altered visual evoked potential (VEP). While the neural substrate for altered VEP in these patients remains elusive, altered V1 structure may play a role. One previous study found a positive relationship between the amplitude of the P100 component of the VEP and V1 surface area, but not V1 thickness, in a small sample of healthy individuals. Here, we aimed to replicate these findings in a larger healthy control (HC) sample (n = 307) and to examine the same relationship in patients with SCZspect (n = 30) or BD (n = 45). We also compared the mean P100 amplitude, V1 surface area and V1 thickness between controls and patients and found no significant group differences. In HC only, we found a significant positive P100-V1 surface area association, while there were no significant P100-V1 thickness relationships in HC, SCZspect or BD. Together, our results confirm previous findings of a positive P100-V1 surface area association in HC, whereas larger patient samples are needed to further clarify the function-structure relationship in V1 in SCZspect and BD.
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Published
Dec. 12, 2023 2:16 PM
- Last modified
Dec. 12, 2023 2:16 PM