Abstract
The neuropeptide oxytocin has historically been associated with reproduction and maternal behavior. However, more recent research has uncovered that oxytocin has a much wider range of roles in physiology and behavior. Despite the excitement surrounding potential therapeutical applications of intranasally administered oxytocin, the results of these intervention studies have been inconsistent. Various reasons for these mixed results have been proposed, which tend to focus on methodological issues, such as study design. While methodological issues are certainly important, emerging evidence suggests that the interaction between oxytocin and sex hormones may also account for these varied findings. To better understand the purpose and function of the interaction of oxytocin with sex hormones, with a focus on estrogens, progesterone, and testosterone, we conducted a comprehensive review via four perspectives: evolutionary, developmental, mechanistic, and survival. Altogether, this synergistic approach highlighted the critical function of sex hormone activity in executing the diverse roles of oxytocin via the modulation of oxytocin release and oxytocin receptor activity. This review illuminates the pivotal role of sex hormone interaction in influencing the varied effects observed after oxytocin administration.
Read the preprint here: https://osf.io/preprints/psyarxiv/9eh28
Citation:
Quintana, D.S., Glaser, B. D., Kang, H., Kildal, E. S., Audunsdottir, K., Sartorius, A. M., & Barth, C. (2024). The interplay of oxytocin and sex hormones. PsyArXiv, https://doi.org/10.31234/osf.io/9eh28