Re-thinking the programming hypothesis

Om prosjektet

Kvinner som venter barn blir stadig advart mot alle mulige farer som kan skade barnet i magen, og både angst og depresjon er blant de vanligste lidelsene hos gravide kvinner.
Selv om konsekvensene av eksponering for mors angst og depresjon på barnets utvikling er godt dokumentert, er årsaksmekanismen som forklarer denne sammenhengen ikke godt forstått.

Dette prosjektet gir en unik mulighet til å forstå hvordan forhold i svangerskapet virker på barnet, samtidig som vi kan kontrollere for forhold etter svangerskapet og genetiske forhold. Prosjektet vil kunne bidra med ny kunnskap om prenatalt stress som kan være av interesse for klinikere og helsepersonell og på lang sikt bidra til å redusere risiko og bidra til at nybakte mødre og barn får en bedre start.

Mål

Formålet med denne studien er å undersøke sammenhengen mellom mors prenatale stress, epigenetiske forhold og forhold hos barn fra spedbarnsalder til ungdomsalder.

Bakgrunn

Prosjektets fulle navn er "Re-thinking the programming hypothesis: Prenatal maternal anxiety/depression, DNA methylation and child psychopathology. A sibling design".

Prosjektet ledes fra Psykologisk Institutt, i samarbeid med partnere fra Folkehelseinstituttet og Manchester Metropolitan University.

Finansiering

Prosjektet finansieres av Norges Forskningsråd (FRIMEDBIO Forskerprosjekt for unge talenter), 2020 - 2024.

Salontaji, Kristina; Haftorn, Kristine Løkås; Sanders, Faye; Page, Christian Magnus; Walton, Esther & Felix, Janine F. [Vis alle 10 forfattere av denne artikkelen] (2024). Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study. Molecular Psychiatry. ISSN 1359-4184. s. 1–8. doi: 10.1038/s41380-024-02544-2.
Hygen, Beate Wold; Skalicka, Vera; Coplan, Robert; von Soest, Tilmann; Fredriksen, Eivor & Bekkhus, Mona (2024). Norwegian Adolescents in the Initial Stages of COVID-19 Restrictions. Links between In-Person vs Digital Interactions, Digital Media Use Loneliness, and Mental Health Problems among . Journal of Media Psychology. ISSN 1864-1105. doi: 10.1027/1864-1105/a000401.
Svendsrud, Hedvig; Fredriksen, Eivor; Moe, Vibeke; Smith, Lars; Tsotsi, Stella & Ullebø, Anne Karin [Vis alle 9 forfattere av denne artikkelen] (2023). Becoming Dad: Expectant Fathers’ Attachment Style and Prenatal Representations of the Unborn Child. Children. ISSN 2227-9067. 10(7). doi: 10.3390/children10071187. Vis sammendrag
How expectant fathers think and feel about the unborn child (prenatal representations), has shown associations with fathers’ postnatal parenting behaviors, observed father–infant interactional quality and child cognitive development. There is limited knowledge about fathers’ prenatal representations. The present study examined if fathers’ partner-related attachment styles were related to their prenatal representations of the unborn child. In the “Little in Norway Study”, an ongoing prospective, longitudinal population-based study, 396 expectant fathers completed the Experiences in Close Relationships Scale at enrollment (mean gestational week = 23.76, SD = 4.93), and in gestational weeks 27–35 completed three questions assessing prenatal representations. Correlations of attachment style and prenatal representations were reported using logistic regression analyses. We found that an avoidant attachment style by fathers were predicted to have absent or negative representations on all three items (1) “strongest feeling about the unborn child” (Cl = 1.19–2.73), (2) “thoughts about child personality” (Cl = 1.16–1.87), and (3) “experiences of relationship with the child” (Cl = 1.14–1.75). Father anxious attachment style was not significantly associated with absent or negative prenatal representations. Results suggest that expectant fathers with a partner related avoidant attachment style have an increased risk of having absent or negative prenatal representations of the unborn child.
Oftedal, Aurora; Tsotsi, Stella; Kaasen, Anne; Kozlowski Mayerhofer, Lilian Juliane; Røysamb, Espen & Smajlagic, Dinka [Vis alle 8 forfattere av denne artikkelen] (2023). Anxiety and depression in expectant parents: ART versus spontaneous conception. Human Reproduction. ISSN 0268-1161. 38(9), s. 1755–1760. doi: 10.1093/humrep/dead133. Fulltekst i vitenarkiv
Tsotsi, Stella; Goh, Shaun; Coplan, Robert J.; Bølstad, Evalill; Czajkowski, Nikolai Olavi & Smajlagic, Dinka [Vis alle 7 forfattere av denne artikkelen] (2023). Co-occurrence of internalizing difficulties and aggression in early childhood and risk of mental health problems in middle childhood. International Journal of Behavioral Development. ISSN 0165-0254. 47(5), s. 384–396. doi: 10.1177/01650254231187902. Fulltekst i vitenarkiv
Oftedal, Aurora; Bekkhus, Mona; Haugen, Guttorm Nils; Hjemdal, Odin; Czajkowski, Nikolai Olavi & Kaasen, Anne (2022). Long-Term Impact of Diagnosed Fetal Anomaly on Parental Traumatic Stress, Resilience, and Relationship Satisfaction. Journal of Pediatric Psychology. ISSN 0146-8693. 48(2), s. 181–192. doi: 10.1093/jpepsy/jsac085. Fulltekst i vitenarkiv Vis sammendrag
Knowledge regarding the long-term psychological adjustment of parents to children with prenatal diagnosis of congenital malformation is scarce. The aim of this study is to examine traumatic stress trajectories, resilience, and relationship satisfaction among parents to children with prenatal diagnosis of a congenital malformation, and to compare this to a sample of non-affected parents. Methods A prospective longitudinal cohort study was conducted at a tertiary perinatal referral center. Ninety-three mothers and 80 fathers who received a diagnosis of fetal anomaly during obstetric ultrasound examination (study group), and 110 mothers and 98 fathers with normal ultrasound findings (comparison group), reported their traumatic stress at four timepoints during pregnancy (T1-T4), 6 weeks after birth (T5), and 10-12 years after birth (T6). Resilience and relationship satisfaction was reported at 10-12 years after birth. Results Parents to children with a congenital malformation experienced significantly elevated traumatic stress levels over time, compared with parents of children without congenital malformation. The difference between groups was largest acutely after diagnosis and remained significant 10-12 years after the birth of the child. Resilience and relationship satisfaction levels were similar in both groups. Conclusions Despite experiencing high levels of traumatic stress over time, parents to children with a congenital malformation reported resilience and relationship satisfaction at similar levels to non-affected parents. This suggests that despite ongoing long-term distress, parents are still able to maintain positive psychological coping resources.
Oftedal, Aurora; Bekkhus, Mona; Haugen, Guttorm Nils; Czajkowski, Nikolai Olavi & Kaasen, Anne (2022). The impact of diagnosed fetal anomaly, diagnostic severity and prognostic ambiguity on parental depression and traumatic stress: a prospective longitudinal cohort study. Acta Obstetricia et Gynecologica Scandinavica. ISSN 0001-6349. 101(11), s. 1291–1299. doi: 10.1111/aogs.14453. Fulltekst i vitenarkiv
Guggenheim, Jeremy A; Clark, Rosie; Zayats, Tetyana; Williams, Cathy & UK BIObank, Eye and vision consortium (2022). Assessing the contribution of genetic nurture to refractive error. European Journal of Human Genetics. ISSN 1018-4813. doi: 10.1038/s41431-022-01126-6.
Clayborne, Zahra M.; Nilsen, Wendy; Torvik, Fartein Ask; Gustavson, Kristin; Bekkhus, Mona & Gilman, Stephen [Vis alle 9 forfattere av denne artikkelen] (2022). Positive maternal mental health attenuates the associations between prenatal stress and children’s internalizing and externalizing symptoms. European Child and Adolescent Psychiatry. ISSN 1018-8827. doi: 10.1007/s00787-022-01999-4. Fulltekst i vitenarkiv
Bekkhus, Mona; Baldwin, Daniella; Coplan, Robert; von Soest, Tilmann; Skaret, Synne & Ulset, Vidar Sandsaunet [Vis alle 7 forfattere av denne artikkelen] (2021). Examining Launch and Snare Effects in the Longitudinal Associations between Shyness and Socio-Emotional Difficulties in Childhood. Social Development. ISSN 0961-205X. doi: 10.1111/sode.12528.
Bekkhus, Mona; Lee, Yunsung; Brandlistuen, Ragnhild Eek; Samuelsen, Sven Ove & Magnus, Per Minor (2021). Maternal Anxiety and Infants Birthweight and Length of Gestation. A sibling design. BMC Psychiatry. ISSN 1471-244X. 21. doi: 10.1186/s12888-021-03620-5. Fulltekst i vitenarkiv

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Smajlagic, Dinka; Tsotsi, Stella; Gjerdevik, Miriam; Page, Christian Magnus; Zayats, Tetyana & Austerberry, Chloe [Vis alle 14 forfattere av denne artikkelen] (2022). Parent-of-origin effects in childhood aggression.
Oftedal, Aurora; Tsotsi, Stella; mayerhofer, lilian; Kaasen, Anne; Smajlagic, Dinka & Bekkhus, Mona (2022). Maternal and paternal anxiety and depression in pregnancies using assisted reproductive technology compared to spontaneous conception.
Tsotsi, Stella; Goh, shaun; Czajkowski, Nikolai Olavi; Smajlagic, Dinka; Coplan, Robert & Bølstad, Evalill [Vis alle 7 forfattere av denne artikkelen] (2022). The co-occurrence of emotional difficulties and aggression in early childhood and the risk of later mental health outcomes: The Norwegian Mother, Father and Child Cohort.
Oftedal, Aurora; Bekkhus, Mona; Haugen, Guttorm Nils & Kaasen, Anne (2022). The development of parental traumatic stress following the detection of fetal anomaly.
Ulset, Vidar Sandsaunet; barker, ted; Smajlagic, Dinka; Zayats, Tetyana; Kraft, Brage & Bekkhus, Mona (2022). Prenatal dietary inflammation, language problems, and ADHD symptoms: Moderating role of polygenic risk. Poster presentation at the 26th Biennial Meeting of the International Society for the Study of Beharvioral Development .
Oftedal, Aurora; Bekkhus, Mona; Haugen, Guttorm Nils & Kaasen, Anne (2022). The impact of diagnosed fetal anomaly, diagnostic severity, and prognostic ambiguity on parental depression and traumatic stress.
Bekkhus, Mona (2021). Flere med alvorlige spiseforstyrrelser og økning i ensomhet og angst. Er sosiale medier synderen. [Avis]. Aftenbladet.
Bekkhus, Mona (2021). Betydningen av vennskap og sosial distansering for ungdom.
Bekkhus, Mona (2020). Forståelsen for de unge under koronarestriksjonene har svikta. [Internett]. Forskning.no.
Bekkhus, Mona (2020). Betaler Isolasjon med ensomhet. [Fagblad]. Psykologitidsskriftet.
Bekkhus, Mona & Skaret, Synne (2020). Betydyningen av sosial sjenanse i barndommen. [Internett]. Utdanningsforskning.no.

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Publisert 28. sep. 2020 20:14 - Sist endret 28. sep. 2020 20:15

Kontakt

Førsteamanuensis Mona Bekkhus