Rene Westerhausen

• Westerhausen, Rene (2024). Dichotic listening and interhemispheric integration after callosotomy: A systematic review. Brain Research. ISSN 0006-8993. 1837. doi: 10.1016/j.brainres.2024.148965.
• Røsvoll, Åsne; Rusten, Emilie Helgeland & Westerhausen, Rene (2024). Left-hand preference in visual artists: A pre-registered observational study on Instagram. Laterality: Asymmetries of Body, Brain and Cognition. ISSN 1357-650X. 29(2), s. 184–198. doi: 10.1080/1357650X.2024.2315856.
• Roe, James Michael; Vidal-Piñeiro, Didac; Amlien, Inge; Pan, Mengyu; Sneve, Markus Handal & de Schotten, Michel Thiebaut [Vis alle 14 forfattere av denne artikkelen] (2023). Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex. eLIFE. ISSN 2050-084X. 12, s. 1–32. doi: 10.7554/eLife.84685.
• Westerhausen, Rene; Fabri, Mara & Hausmann, Markus (2023). Dichotic-listening performance after complete callosotomy: No relief from left-ear extinction by selective attention. Neuropsychologia. ISSN 0028-3932. 188. doi: 10.1016/j.neuropsychologia.2023.108627. Fulltekst i vitenarkiv
• Vingerhoets, Guy; Verhelst, Helena; Gerrits, Robin; Badcock, Nicholas; Bishop, Dorothy V. M. & Carey, David [Vis alle 15 forfattere av denne artikkelen] (2023). Laterality indices consensus initiative (LICI): A Delphi expert survey report on recommendations to record, assess, and report asymmetry in human behavioural and brain research. Laterality: Asymmetries of Body, Brain and Cognition. ISSN 1357-650X. doi: 10.1080/1357650X.2023.2199963. Fulltekst i vitenarkiv
• Raaf, Nora & Westerhausen, Rene (2023). Hand preference and the corpus callosum: Is there really no association? Neuroimage: Reports. ISSN 2666-9560. 3(1), s. 1–11. doi: 10.1016/j.ynirp.2023.100160.
• Westerhausen, Rene (2022). Interhemispheric Integration after Callosotomy: A Meta-Analysis of Poffenberger and Redundant-Target Paradigms. Neuropsychology Review. ISSN 1040-7308. doi: 10.1007/s11065-022-09569-w.
• Hopkins, William D.; Westerhausen, Rene; Schapiro, Steve & Sherwood, Chet C. (2022). Heritability in corpus callosum morphology and its association with tool use skill in chimpanzees (Pan troglodytes): Reproducibility in two genetically isolated populations. Genes, Brain and Behavior. ISSN 1601-1848. 21(2). doi: 10.1111/gbb.12784.
• Sha, Zhiqiang; Pepe, Antonietta; Schijven, Dick; Carrion-Castillo, Amaia; Roe, James Michael & Westerhausen, Rene [Vis alle 10 forfattere av denne artikkelen] (2021). Handedness and its genetic influences are associated with structural asymmetries of the cerebral cortex in 31,864 individuals. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 118(47), s. 1–9. doi: 10.1073/pnas.2113095118. Fulltekst i vitenarkiv
• Vidal-Piñeiro, Didac; Wang, Yunpeng; Krogsrud, Stine Kleppe; Amlien, Inge; Baaré, William FC & Bartres-Faz, David [Vis alle 31 forfattere av denne artikkelen] (2021). Individual variations in ‘brain age’ relate to early-life factors more than to longitudinal brain change. eLIFE. ISSN 2050-084X. 10. doi: 10.7554/eLife.69995. Fulltekst i vitenarkiv
• Westerhausen, René & Papadatou-Pastou, Marietta (2021). Handedness and midsagittal corpus callosum morphology: a meta-analytic evaluation. Brain Structure and Function. ISSN 1863-2653. doi: 10.1007/s00429-021-02431-4.
• Fjell, Anders Martin; Grydeland, Håkon; Wang, Yunpeng; Amlien, Inge; Bartrés-Faz, David & Brandmaier, Andreas M. [Vis alle 24 forfattere av denne artikkelen] (2021). The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan running title: Genetics of subcortical lifespan change. eLIFE. ISSN 2050-084X. 10, s. 1–22. doi: 10.7554/eLife.66466. Fulltekst i vitenarkiv Vis sammendrag

  Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single-nucleotide polymorphisms-based analyses of 38,127 cross-sectional MRIs showed a similar pattern of genetic volume–volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.

• Walhovd, Kristine Beate; Fjell, Anders Martin; Wang, Yunpeng; Amlien, Inge; Mowinckel, Athanasia Monika & Lindenberger, Ulman [Vis alle 29 forfattere av denne artikkelen] (2021). Education and income show heterogeneous relationships to lifespan brain and cognitive differences across European and US cohorts. Cerebral Cortex. ISSN 1047-3211. 32(4), s. 839–854. doi: 10.1093/cercor/bhab248. Fulltekst i vitenarkiv
• Roe, James Michael; Vidal-Piñeiro, Didac; Sørensen, Øystein; Brandmaier, Andreas M.; Düzel, Sandra & Gonzalez, Hector A. [Vis alle 18 forfattere av denne artikkelen] (2021). Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease. Nature Communications. ISSN 2041-1723. 12:721, s. 1–11. doi: 10.1038/s41467-021-21057-y. Fulltekst i vitenarkiv
• Westerhausen, René & Meguerditchian, Adrien (2021). Corpus callosum morphology across the lifespan in baboons (Papio anubis): A cross-sectional study of relative mid-sagittal surface area and thickness. Neuroscience research. ISSN 0168-0102. s. 1–8. doi: 10.1016/j.neures.2021.03.002.
• Sørensen, Øystein; Brandmaier, Andreas M.; Macià, Dídac; Ebmeier, Klaus; Ghisletta, Paolo & Kievit, Rogier A. [Vis alle 10 forfattere av denne artikkelen] (2021). Meta-analysis of generalized additive models in neuroimaging studies. NeuroImage. ISSN 1053-8119. doi: 10.1016/j.neuroimage.2020.117416. Vis sammendrag

  Analyzing data from multiple neuroimaging studies has great potential in terms of increasing statistical power, enabling detection of effects of smaller magnitude than would be possible when analyzing each study separately and also allowing to systematically investigate between-study differences. Restrictions due to privacy or proprietary data as well as more practical concerns can make it hard to share neuroimaging datasets, such that analyzing all data in a common location might be impractical or impossible. Meta-analytic methods provide a way to overcome this issue, by combining aggregated quantities like model parameters or risk ratios. Most meta-analytic tools focus on parametric statistical models, and methods for meta-analyzing semi-parametric models like generalized additive models have not been well developed. Parametric models are often not appropriate in neuroimaging, where for instance age-brain relationships may take forms that are difficult to accurately describe using such models. In this paper we introduce meta-GAM, a method for meta-analysis of generalized additive models which does not require individual participant data, and hence is suitable for increasing statistical power while upholding privacy and other regulatory concerns. We extend previous works by enabling the analysis of multiple model terms as well as multivariate smooth functions. In addition, we show how meta-analytic p-values can be computed for smooth terms. The proposed methods are shown to perform well in simulation experiments, and are demonstrated in a real data analysis on hippocampal volume and self-reported sleep quality data from the Lifebrain consortium. We argue that application of meta-GAM is especially beneficial in lifespan neuroscience and imaging genetics. The methods are implemented in an accompanying R package metagam, which is also demonstrated.

• Westerhausen, Rene & Samuelsen, Fredrik Andre Lundgård (2020). An optimal dichotic-listening paradigm for the assessment of hemispheric dominance for speech processing. PLOS ONE. ISSN 1932-6203. 15:: e0234665(6), s. 1–11. doi: 10.1371/journal.pone.0234665. Fulltekst i vitenarkiv
• Danielsen, Vilde Marie; Vidal-Piñeiro, Didac; Mowinckel, Athanasia Monika; Sederevicius, Donatas; Fjell, Anders Martin & Walhovd, Kristine B [Vis alle 7 forfattere av denne artikkelen] (2020). Lifespan trajectories of relative corpus callosum thickness: Regional differences and cognitive relevance. Cortex. ISSN 0010-9452. 130, s. 127–141. doi: 10.1016/j.cortex.2020.05.020. Vis sammendrag

  The cerebral hemispheres are specialized for different cognitive functions and receive divergent information from the sensory organs, so that the interaction between the hemispheres is a crucial aspect of perception and cognition. At the same time, the major fiber tract responsible for this interaction, the corpus callosum, shows a structural development across the lifespan which is over-proportional. That is, compared to changes in overall forebrain volume, the corpus callosum shows an accentuated growth during childhood, adolescence, and early adulthood, as well as pronounced decline in older age. However, this over-proportionality of growth and decline along with potential consequences for cognition, have been largely overlooked in empirical research. In the present study we systematically address the proportionality of callosal development in a large mixed cross-sectional and longitudinal sample (1867 datasets from 1014 unique participants), covering the human lifespan (age range 4–93 years), and examine the cognitive consequences of the observed changes. Relative corpus callosum thickness was measured at 60 segments along the midsagittal surface, and lifespan trajectories were clustered to identify callosal subsections of comparable lifespan development. While confirming the expected inverted u-shaped lifespan trajectories, we also found substantial regional variation. Compared with anterior clusters, the most posterior sections exhibited an accentuated growth during development which extends well into the third decade of life, and a protracted decline in older age which is delayed by about 10 years (starting mid to late 50s). We further showed that the observed longitudinal changes in relative thickness of the mid splenium significantly mediates age-related changes in tests assessing verbal knowledge and non-verbal visual-spatial abilities across the lifespan. In summary, we demonstrate that analyzing the proportionality of callosal growth and decline offers valuable insight into lifespan development of structural connectivity between the hemispheres, and suggests consequences for the cognitive development of perception and cognition.

• Gorbach, Tetiana; Pudas, Sara; Bartrés-Faz, David; Brandmaier, Andreas M.; Düzel, Sandra & Henson, Rik [Vis alle 17 forfattere av denne artikkelen] (2020). Longitudinal association between hippocampus atrophy and episodic‐memory decline in non‐demented APOE ε4 carriers. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. ISSN 2352-8729. 12(1). doi: 10.1002/dad2.12110. Fulltekst i vitenarkiv Vis sammendrag

  Introduction The apolipoprotein E (APOE) ε4 allele is the main genetic risk factor for Alzheimer's disease (AD), accelerated cognitive aging, and hippocampal atrophy, but its influence on the association between hippocampus atrophy and episodic‐memory decline in non‐demented individuals remains unclear. Methods We analyzed longitudinal (two to six observations) magnetic resonance imaging (MRI)–derived hippocampal volumes and episodic memory from 748 individuals (55 to 90 years at baseline, 50% female) from the European Lifebrain consortium. Results The change‐change association for hippocampal volume and memory was significant only in ε4 carriers (N = 173, r = 0.21, P = .007; non‐carriers: N = 467, r = 0.073, P = .117). The linear relationship was significantly steeper for the carriers [t(629) = 2.4, P = .013]. A similar trend toward a stronger change‐change relation for carriers was seen in a subsample with more than two assessments. Discussion These findings provide evidence for a difference in hippocampus‐memory association between ε4 carriers and non‐carriers, thus highlighting how genetic factors modulate the translation of the AD‐related pathophysiological cascade into cognitive deficits.

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• Roe, James Michael; Vidal-Piñeiro, Didac; Sørensen, Øystein; Brandmaier, Andreas M.; Düzel, Sandra & Gonzalez, Hector A. [Vis alle 78 forfattere av denne artikkelen] (2022). Author Correction: Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease (Nature Communications, (2021), 12, 1, (721), 10.1038/s41467-021-21057-y). Nature Communications. ISSN 2041-1723. 13(1). doi: 10.1038/s41467-022-28514-2.

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